Fiscal Year (FY) 2010
|Project Title:||Effect of Dehydration and Heat Stress on Vascular and Hemostatic Functions|
|Principle Investigator:||Denise Smith, Ph.D|
|Period of Performance:||06/12/2011 – 06/11/2013|
This study will investigate the effect of dehydration and heat stress on factors that are mechanistically linked to sudden cardiac events and that have been shown to be altered by firefighting activity.
There has been no scientific study of the effect of dehydration or heat stress on arterial function and hemostatic responses to muscular effort. Designing interventions to mitigate deleterious arterial and hemostatic changes requires an understanding of the independent influences of dehydration and heat stress on these parameters. This study aims to examine the independent and combined effects of dehydration and alteration in core temperature on vascular function and hemostatic responses to maximal exercise.
In order to investigate the effect of dehydration and heat stress on arterial and hemostatic function, the study will employ a repeated measures design and will require the participant to perform 4 exercise trials: a) normal body temperature and normal hydration, b) normal body temperature and dehydrated, c) elevated body temperature and normal hydration, and d) elevated body temperature and dehydration.
Projected Results and Conclusions:
It is hypothesized that dehydration and hyperthermia will have detrimental effects on arterial function and will lead to increased coagulatory potential. Determining the contributions of these twin challenges allows recommendations for specific interventions that will lessen arterial and hemostatic disruptions associated with firefighting.
07/24/2014 - 16:00